IRCCS Centro Neurolesi Bonino Pulejo,located in Messina (Italy), established in 1992 and recognized by Italy’s Ministry of Health as an Institute of Hospitality and Care, is a leading neuro-rehabilitation institute. It became a public institute in 1997, excelling in healthcare delivery and scientific research. The Center is noted also for its advanced technological capabilities in robotics and virtual reality, essential for treating severe acquired brain injuries and neurodegenerative diseases.